Provisional estimates show drug overdose deaths declined about 3.1% nationwide, but multiple states reported increases of more than 20%.
The Centers for Disease Control and Prevention's provisional estimated overdose deaths in 2023 declined about 3.1% to 107,543. That's down from 111,029 in 2022. Two out of every three deaths involved synthetic opioids such as fentanyl, a cheap and potent opioid smuggled into the U.S. from Mexico.
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